Gene discovery, gene expression and product manufacturing using an integrated fungal host system

Proteins are an increasingly important source of new products for numerous industries, including human and animal health, diagnostics, health and beauty aids, agricultural products, and chemicals. Because of the functional roles of proteins in living systems, proteins represent a large fraction of all biologically active molecules and the entire spectrum of biological activities. To exploit these properties to bring new products to these industries, there is an increasing demand for biological systems to discover, develop and manufacture proteins. Currently, there are a variety of systems available to perform discovery, development and manufacturing steps individually. However, some of these systems are limited with regards their abilities to discover and express genes from a large portion of the protein ‘universe’. Others are impractical for commercial production of many proteins because of restrictive conditions necessary for growth and cultivation of the biological systems or the inability of those systems to produce proteins economically at large commercial scale.